Endocrine and Metabolic Response to Shock and Trauma.
Annual progress rept. 1 Oct 77-30 Sep 78,
BOSTON UNIV MASS SCHOOL OF MEDICINE
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Hemorrhagic shock-induced insulin resistance and alterations in muscle leucine oxidation and protein synthesis occurred in pancreatectomized and adrenalectomized monkeys despite prevention of shock-induced alterations in pancreatic or adrenal hormone secretion through the constant infusion of insulin and cortisol. Muscle and general protein metabolism were studied in rhesus monkeys postoperatively with and without adequate nutrition including amino acids. It was concluded that the provision of adequate amounts of amino acids improves the post-traumatic nitrogen balance in primates probably by reducing muscle hypercatabolism. Circadian rhythms for cortisol were studied in 5 monkeys before and after hemorrhagic shock. In only one animal was a circadian pattern seen in the control period, possibly due to technical difficulties. Interestingly, in the post-shock period 4 of the monkeys exhibited characteristic circadian rhythms. Author
- Medicine and Medical Research