Accession Number:

ADA063169

Title:

Immunoglobulins in Periodontal Tissues. III. Concentrations of Immunoglobulins in Dilantin Induced and Idiopathic Gingival Hyperplastic Tissues.

Descriptive Note:

Rept. for 15 Jun 75-12 Dec 78,

Corporate Author:

ARMY INST OF DENTAL RESEARCH WASHINGTON D C

Personal Author(s):

• Setterstrom,Jean A.
• Gross,Arthur
• D'Alessandro,Sandra M.
• Godat,R. F.

Report Date:

1978-12-12

Pagination or Media Count:

22.0

Abstract:

Diphenylhydantoin sodium Dilantin, prescribed for extended periods of time for the treatment of epilepsy, frequently produces side effects and idiosyncratic reactions. Nystagmus, blurred vision, slurred speech, and ataxia are dose related side effects which usually subside following drug withdrawal. Skin rashes accompanying manifestations of allergy to Dilantin have been reported in 5-10 of patients. Depression of one or more parameters of the cellular andor humoral immune response has been described as occurring in 60. Rarer reactions such as aplastic anemia, systemic lupus erythematosus, erythema multiforme, and Stevens-Johnson syndrome also occur. Fibrous hyperplasia of the gingiva occurs in 57 of patients on Dilantin therapy who are less than 26 years of age, but only in 21 of those who are older.

Descriptors:

• *DRUGS
• *IMMUNOGLOBULINS
• TISSUES(BIOLOGY)
• THERAPY
• PATIENTS
• EPILEPSY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE