Accession Number:

ADA062015

Title:

Mammalian Toxicity of Munition Compounds. Phase II. Effects of Multiple Doses. Part III. 2,6-Dinitrotoluene

Descriptive Note:

Progress rept. no. 4, 15 Nov 74-30 Apr 76

Corporate Author:

MIDWEST RESEARCH INST KANSAS CITY MO

Report Date:

1976-07-01

Pagination or Media Count:

160.0

Abstract:

The effects of oral doses of 2,6-dinitrotoluene 2,6-DNT after administration to dogs, rats and mice for up to 13 weeks were studied. The effects of 2,6-DNT on drug metabolizing enzymes in rats were also studied. In dogs, 4 mgkgday was slightly toxic 20 mgkgday was very toxic and lethal to some 100 mgkgday was lethal to all within 8 weeks. In rats, 7 mgkgday had no effects, 35 males or 37 females mgkgday and 145 males or 155 females mgkgday had dose-related toxicity. In mice, 11 mgkgday had no effect, while 51 males or 55 females mgkgday and 289 males or 299 females mgkgday had dose-related toxicity. Target organs included the blood methemoglobin and sequelae, testes depressed spermatogenesis, liver degeneration, bile duct hyperplasia, neuromuscular system incoordination and rigid paralysis and kidney degeneration. Toxic doses of 2,6-DNT in rats increased drug-metabolizing enzyme activity in rat liver. Author

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE