The Synergistic Effect of Ultrasound and Ionizing Radiation on Human Lymphocytes.
AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OHIO
Pagination or Media Count:
Lymphocytes in human peripheral blood were exposed to various combinations and sequences of heat, ultrasound andor ionizing radiation and their chromosomes analyzed for gross chromosomal aberrations. The combined use of ultrasound and ionizing radiation showed a statistically significant increase in exchange aberrations for the simultaneous ultrasound 3.0 Wsq cm, CW, 1.1 MHz and ionizing radiation 300 and 100 rads, Co-60, 120 radsmin exposures. Ultrasound used before or after irradiation caused no aberrations and extending the time of ultrasound exposure after irradiation had no effect over that of the ultrasound only during the radiation exposure. The combined use of 43 C heat same temperature as that induced by 3.0 Wsq cm, CW, 1.1 MHz ultrasound and ionizing radiation showed basically the same significant results as the combined ultrasound and ionizing radiation exposures. In addition, the combined use of heat at various temperatures 24 C thru 43 C and ionizing radiation showed that all chromosome aberration types and the number of aberrant metaphase figures increased with increasing temperature. A statistical comparison of the heat plus ionizing radiation and the ultrasound plus ionizing radiation exposures showed no statistically significant difference between heat or ultrasound for any type aberration. Author