Accession Number:

ADA061525

Title:

Myocardial Function in Endotoxin Shock.

Descriptive Note:

Technical rept.,

Corporate Author:

OKLAHOMA UNIV HEALTH SCIENCES CENTER OHLAHOMA CITY DEPT OF PHYSIOLOGY AND BIOPHYSICS

Personal Author(s):

Report Date:

1978-08-28

Pagination or Media Count:

26.0

Abstract:

Coronary hypoperfusion and depressed responses to beta adrenergic stimuli are prime factors in the elicitation of cardiac dysfunction. Intracardiac disturbances perform a major role but their causes are obscure. Associated together in this latter category are the development of edema in the myocardium occurring in both the contractile elements and mitochondria ionic imbalances of potassium and probably calcium and elevations of left ventricular end diastolic pressure and depressions of negative dPdt sub max, cardiac power and efficiency. The interactions and additive effects of these factors are responsible for the development of myocardial dysfunction in endotoxin shock. Author

Subject Categories:

  • Anatomy and Physiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE