Accession Number:

ADA059837

Title:

Syphilis Vaccine and Immune Mechanisms.

Descriptive Note:

Final rept. 1 Apr 72-31 Dec 77,

Corporate Author:

CALIFORNIA UNIV LOS ANGELES DEPT OF MICROBIOLOGY AND IMMUNOLOGY

Personal Author(s):

Report Date:

1977-12-31

Pagination or Media Count:

46.0

Abstract:

Although complete immunity can be accomplished in rabbits by immunizing intravenously with 60 injections of freshly isolated, gamma-irradiated T. pallidum over a 37 week period, no significant protection was achieved when the gamma-irradiated treponemes were preserved in liquid nitrogen and used as immunizing agents, with or without an alginate-gluconate adjuvant, in a practical injection and time schedule vaccinated animals produced both VDRL and FTA-ABS antibodies, but not TPI antibody.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE