Mechanism of Bacterial Killing by the Peritoneal and Hepatic Macrophage Population: Oxidative Bactericidal Mechanisms of Phagocytic Cells.
Final progress rept. 1 Jan 74-31 Dec 76,
NEW ENGLAND MEDICAL CENTER HOSPITAL BOSTON MASS
Pagination or Media Count:
The overall purpose of this project is to understand the means by which phagocytes kill bacteria. The particular goal since the beginning of the report period has been to develop a system to examine the effect of oxygen tension on the respiratory burst of neutrophils. Previous studies showed that the methods we had used to provide a hypoxic or anoxic environment for neutrophils to work in had led to damage to the cells. During the project period, we were able to devise a technique for incubating neutrophils under hypoxic conditions, and examined the relationship between oxygen tension and O2 production by these cells. Author
- Anatomy and Physiology