Accession Number:

ADA058568

Title:

Investigation of 'Escherichia coli' Enterotoxins

Descriptive Note:

Final rept. 1 Aug 1973-30 Sep 1977

Corporate Author:

WYETH LABS INC PHILADELPHIA PA

Personal Author(s):

Report Date:

1978-05-01

Pagination or Media Count:

16.0

Abstract:

The results of the present investigation indicate a new approach to the development of a single vaccine formula which may ultimately be used to confer protection against both cholera and E. coli diarrheal disease in man and domestic animals. Fundamentally, the design of the vaccine is based on the well- documented ability of cholera antitoxin to neutralize both cholera and heat- labile E. coli enterotoxins and on the ability of certain E. coli antigens to enhance the immune response to cholera toxoid and possibly whole-cell Cholera Vaccine, as well.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE