Studies on the Antigenic Composition of 'Coxiella burnetii'.
Annual progress rept. 1 Jul 77-30 Jun 78,
WASHINGTON STATE UNIV PULLMAN
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It has been possible to employ the mouse as a model for vaccine development in the Coxiella burnetii system. Resistance to re-infection can be demonstrated in infected-recovered mice as well as mice that have been immunized with formalin-killed cells. This immunity can be ascertained by accelerated clearance of viable C. burnetii from spleen and liver in challenged animals. The accelerated clearance is apparently not due to antibody levels alone. Studies with passively administered antibody in normal mice or infection studies in the nude mouse system indicate a cooperative need with a functioning lymphocytic-macrophage system. We have isolated by Triton X-100 extraction, material from C. burnetii that is immunogenic and has some protective activity. This is a preliminary observation that is currently being confirmed. Author