Accession Number:

ADA056778

Title:

Morphologic and Biochemical Effects of Oxygen Toxicity.

Descriptive Note:

Final rept. 1 Apr 68-30 Nov 74,

Corporate Author:

ALBERT EINSTEIN COLL OF MEDICINE BRONX NY DEPT OF PATHOLOGY

Personal Author(s):

• Rosenbaum,Robert M.
• Wittner,Murray

Report Date:

1978-03-01

Pagination or Media Count:

49.0

Abstract:

Morphologic and biochemical studies dealing with effects of high O2 concentrations were made on a wide range of cell types including protozoa, mammalian cell lines, lung cells and marine invertebrate and amphibian eggs. Studies were aimed at evaluating effects of O2 on proteolysis of cells, on mitoses, on DNA, RNA and protein synthesis, on the etiology of alveolar lining cell injury, and on the development of O2 tolerance in rats. Peripheral areas related to these studies dealt with the demonstration of different subgroups of the same family of some acid hydrolases and effects of O2 on the two pathways of serotonin metabolism. Ultrastructural studies stressed the conformational changes of mitochondria in type 2 cells of tolerant rats and sequence of O2 induced injury at the level of terminal airway. Author

Descriptors:

• *TOXICITY
• *BIOCHEMISTRY
• *OXYGEN
• *CONCENTRATION(CHEMISTRY)
• *MORPHOLOGY(BIOLOGY)
• AMPHIBIANS
• TISSUE CULTURE CELLS
• MAMMALS
• PROTEINS
• SYNTHESIS(CHEMISTRY)
• DEOXYRIBONUCLEIC ACIDS
• IN VITRO ANALYSIS
• LUNG
• EGGS
• CELLS(BIOLOGY)
• INVERTEBRATES
• RIBONUCLEIC ACIDS
• LABORATORY ANIMALS
• MITOSIS

Subject Categories:

• Animal Husbandry and Veterinary Medicine
• Biochemistry
• Anatomy and Physiology
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE