Adjuvant Effects on Immune Responses to Biologic Agents.
Annual progress rept. 1 Jul 77-30 Jun 78,
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE
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Morphologic, immunologic and radiokinetic studies have been carried out to provide new insight into the bioregulation of lymphocyte traffic in normal animals and how this may be modified by adjuvants to potentiate immune responses to vaccines. The membrane determinants of lymphocyte homing are analyzed and evidence is presented for the cytoskeletal control of these cellular interactions. Data are presented supporting the concept that scrubbing of lymphocyte surfaces by high endothelial cells may be an important but previously unrecognized phenomenon for the successful initiation of in vivo immune responses. The possible role of chemotaxis in regulating the entry and redistribution of lymphocyte subpopulations into different anatomical regions of peripheral lymph nodes is analyzed. Studies of the mechanisms by which complete freunds adjuvant enhances immune responses to VEE have been combined with surgical thymectomy to demonstrate that the ablation of T-cell suppressor effects can potentiate immune responses initiated by vaccine in adjuvant.