Accession Number:

ADA056537

Title:

Comparision of Aerosol and Intramuscular Kanamycin Treatment of Respiratory 'Klebsiella pneumoniae' Infection in a Subhuman Primate.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s):

• Berendt,R. F.
• Schneider,M. A.
• Frola,F. R.
• Young,H. W.
• Powanda,M. C.

Report Date:

1978-06-06

Pagination or Media Count:

27.0

Abstract:

The objective of this study was to compare the efficacy of i.m.- and aerosol-administered kanamycin for the treatment of pneumonia due to Klebsiella pneumoniae in the squirrel monkey. Both routes were equally effective in preventing mortality, inhibiting bacteremia and pharyngeal shedding of organisms and in reducing fever. Aerosol treatment seemed to cause tachypnea in infected monkeys, whereas anorexia was more notable in some of the monkeys treated i.m. In view of their approximately equal effect, the i.m. must be the preferred route of treatment rather than the aerosol. Author

Descriptors:

• *RESPIRATORY DISEASES
• *ANTIBIOTICS
• *KLEBSIELLA PNEUMONIAE
• AEROSOLS
• THERAPY
• SQUIRREL MONKEYS

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE