Accession Number:

ADA056458

Title:

Research on Immunization Against African Sleeping Sickness,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH UNIT (KENYA)

Personal Author(s):

• Kovatch,Robert M.
• Wellde,Bruce T.
• Hockmeyer,Wayne T.

Report Date:

1978-06-01

Pagination or Media Count:

15.0

Abstract:

It has been demonstrated that the antigenic character of the parasite population of T. rhodesiense from an endemic area was composed of perhaps as few as one serodeme which was antigenically stable over an 8-year period. It was also found that immunity can be induced to blood and tsetse fly metacyclic forms by exposure of experimental animals to a broad spectrum of antigenic variants of the same serodeme. The sterile immunity described in these studies was long lasting. It is believed that these findings enhance the likelihood of immunologic control of trypanosomiasis.

Descriptors:

• *TRYPANOSOMA
• *TRYPANOSOMIASIS
• NEUTRALIZATION
• DRUGS
• IMMUNIZATION
• PARASITIC DISEASES
• SLEEP
• LABORATORY ANIMALS

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE