Accession Number:

ADA056085

Title:

A Study of Adverse Gastrointestinal Effects of 8-Aminoquinolines.

Descriptive Note:

Annual rept. 1 May 76-1 Jun 77,

Corporate Author:

ALABAMA UNIV MEDICAL CENTER BIRMINGHAM

Personal Author(s):

• Teague,Robert S.
• Mundy,Roy L.
• Seidel,Edward R.

Report Date:

1977-09-01

Pagination or Media Count:

55.0

Abstract:

Investigations were carried out in an attempt to uncover the mechanism of primaquine-induced gastrointestinal discomfort reported in humans after oral administration of the compound. Primaquine did not alter recordings of gastrointestinal motor activity in unanesthetized rats or dogs. Primaquine acted as an analgesic in the mouse writhing test. It was reported that primaquine was a surmountable antagonist of acetylcholine in the isolated guinea pig gall bladder. Cholecystokinin was shown to potentiate the action of acetylcholine in the isolated guinea pig gall bladder, WR 6890, a congener of primaquine 6-hydroxy-8-aminoquinoline, neither contracted nor relaxed the isolated guinea pig ileum or gall bladder and had no effect on the sensitivity of these organs to acetylcholine. The results of these experiments do not explain the mechanism of primaquine-induced distress. Author

Descriptors:

• *AMINES
• *ANTIMALARIALS
• *QUINOLINES
• *PRIMAQUINE
• PHYSIOLOGICAL EFFECTS
• GASTROINTESTINAL SYSTEM

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE