Accession Number:

ADA055958

Title:

Biochemical Analysis of Cerebrospinal Fluid Changes in Response to Drug Administration.

Descriptive Note:

Final rept. 1 Jun 74-30 Nov 75,

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD

Personal Author(s):

• Burns,Barry
• Meyerhoff,James L.
• Lennox,Robert W.

Report Date:

1978-05-01

Pagination or Media Count:

36.0

Abstract:

The objectives of this study were to quantify the cerebrospinal fluid CSF biochemical changes in response to drug administration in rhesus monkeys. CSF was collected at hourly intervals over a period of neurotransmitter metabolites HMPG, HVA and the nucleotides C-AMP and C-GMP. Drug administration caused changes in the measured parameters. Author

Descriptors:

• *CEREBROSPINAL FLUID
• MEASUREMENT
• BIOCHEMISTRY
• RESPONSE(BIOLOGY)
• RHESUS MONKEYS
• NUCLEOTIDES
• HEROIN
• AMPHETAMINES
• PENTOBARBITAL

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE