Accession Number:

ADA055683

Title:

A Literature Review - Problem Definition Studies on Selected Toxic Chemicals. Volume 3. Occupational Health and Safety Aspects of 2,4,6-Trinitrotoluene (TNT)

Descriptive Note:

Final rept. Mar 1977-Apr 1978

Corporate Author:

FRANKLIN INST RESEARCH LABS PHILADELPHIA PA SCIENCE INFORMATION SERVICES DEPT

Report Date:

1978-04-01

Pagination or Media Count:

123.0

Abstract:

A literature review 224 references assessing occupational health and safety aspects of TNT 2,4,6-trinitrotoluene. Topics considered include human toxicity, epidemiology of TNT occupational exposures, industrial standards and practices delimited by the OSHA Act and U.S. Armed Forces recommendations on maximum allowable concentration of atmospheric TNT in the workplace. Laboratory animal morbidity and mortality studies, pharmacokinetics in mammals, microbial biodegradation, photodecomposition and other environmental aspects, and sampling and analysis in biologic media, air and water are reviewed. Recommendations for further research include determination of the carcinogenic, mutagenic and teratogenic potential of TNT, and establishment of a lower maximum allowable concentration in the workplace from 1.5 mgcu m to 0.5 mgcu m atmospheric TNT to reduce the occurrence of dose-related aplastic anemia, toxic hepatitis and jaundice, and other manifestations of intoxication from short- or long-term occupational exposure to TNT.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE