Accession Number:

ADA055110

Title:

The Effects of Acute Alterations in Hemodynamics, Oxygen Availability, and Acid-Base Balance in the Permeability of the Gastric Mucosa.

Descriptive Note:

Annual progress rept. 1 Oct 77-30 Sep 78,

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1978-05-24

Pagination or Media Count:

7.0

Abstract:

Using a previously described model for acute gastric mucosal ulcerogenesis Gastroent.68699, 1975, studies carried out in this laboratory indicate that acute gastric mucosal ulcerogenesis may be a consequence of uncompensated tissue acidosis that the topical application of 16,16 DM PGE2 significantly ameliorates bile acid-ischemia induced acute mucosal lesion formation and that intravenous metiamide is cyto-protective under the same circumstances, perhaps as a consequence of its ability to decrease the apparent permeability of the gastric mucosa to cations.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE