Quantitative Studies of Microembolization in Man During Surgical Trauma.
Annual rept. Mar 77-Feb 78,
BAYLOR COLL OF MEDICINE HOUSTON TX
Pagination or Media Count:
The present annual report describes recently completed studies of microembolization and platelet aggregation resulting from surgical trauma. A study of patients following induction of anesthesia and thoracotomy indicated increased platelet reactivity associated with development of lower platelet counts, while preanesthetic agents and intravenous heparinization had no effect on the platelets. Experimental animal studies indicated that platelet reactivity increased with alkalosis and hypoxia, decreased with respiratory acidosis, but was unchanged by metabolic acidosis. An in vitro study demonstrated that the mean size of platelet aggregates generated by shear stress in a rotational viscometer varied inversely with increased stress, while subsequent aggregation in response to adenosine diphosphate was progressively inhibited. Author
- Medicine and Medical Research