Accession Number:

ADA053426

Title:

Quantitative Studies of Microembolization in Man During Surgical Trauma.

Descriptive Note:

Annual rept. Mar 77-Feb 78,

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

1978-03-01

Pagination or Media Count:

23.0

Abstract:

The present annual report describes recently completed studies of microembolization and platelet aggregation resulting from surgical trauma. A study of patients following induction of anesthesia and thoracotomy indicated increased platelet reactivity associated with development of lower platelet counts, while preanesthetic agents and intravenous heparinization had no effect on the platelets. Experimental animal studies indicated that platelet reactivity increased with alkalosis and hypoxia, decreased with respiratory acidosis, but was unchanged by metabolic acidosis. An in vitro study demonstrated that the mean size of platelet aggregates generated by shear stress in a rotational viscometer varied inversely with increased stress, while subsequent aggregation in response to adenosine diphosphate was progressively inhibited. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE