Accession Number:

ADA052694

Title:

Oxazinediones and Related Compounds as Antimalarial Agents.

Descriptive Note:

Final rept. 1974-1976,

Corporate Author:

TEMPLE UNIV PHILADELPHIA PA

Personal Author(s):

Report Date:

1978-04-04

Pagination or Media Count:

87.0

Abstract:

Objective- To develop new chemical agents for the treatment of malaria and related parasitic diseases by preparing samples of new organic compounds for testing against murine malaria. Rationale- Because simple derivatives of compounds containing the oxazinedione ring system were known to exhibit inhibitory activity in E. coli. and other microorganisms, it was hoped that a systematically prepared group of derivatives of oxazinediones would include compounds of activity against Plasmodia.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE