Chemotherapy of 'Trypanosoma rhodesiense'.
Rept. no. 2(Annual), 1 Jun 73-31 May 74,
MIAMI UNIV FLA LEO RANE RESEARCH LAB
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The test system described herein was developed specifically to evaluate the trypanosomicidal activity of large numbers of candidate compounds. Based on blood-induced Trypanosoma rhodesiense infections in mice, it performs as a primary screen or as a secondary screen and confirmatory test and gives precise quantitative evaluations of chemical compounds that demonstrate potentially useful therapeutic andor prophylactic activity in T. rhodesiense infections. Consequently, it is also a helpful guideline in the synthesis of new active agents. These agents include 1 chemicals structurally related to compounds of known value in the treatment or prevention of T. rhodesiense infections 2 chemicals structurally unrelated to compounds of known value in the treatment or prevention of T. rhodesiense infections and 3 structural analogues of compounds that have demonstrated activity in our screening procedure and represent novel chemical groups.