Metabolic and Endocrine Changes in Hepatic Schistosomiasis.
ALEXANDRIA UNIV (EGYPT) FACULTY OF MEDICINE
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In hepatic schistosomiasis the glucose disappearance rate was slower than in controls, plasma insulin levels were comparable to that of controls up to 60 minutes after glucose loading and higher at 90 minutes, growth hormone levels were comparable to controls and free fatty acids significantly higher. Total lipids, cholesterol, phospholipids, triglycerides and alpha-lipoproteins were significantly lower than in controls. The mean total lipids, cholesterol and phospholipids were significantly lower in patients with collaterials than in patients without, the difference disappeared after decongestion operation. Fat tolerance tests showed less triglyceride increment in schistosomiasis and greater rise of free fatty acids with rapid elimination. The lipoprotein lipase activity was decreased and the total phospholipid value and their fractions differed from that of controls. Albumin was decreased in hepatic schistosomiasis while the globulins were increased. Serum amino acids showed significant decrease of glutamine, glutamic acid and valine. Severe impairment of ammonia tolerance correlated with increase transaminases levels. Author
- Anatomy and Physiology
- Medicine and Medical Research