Accession Number:

ADA051765

Title:

Fixed Ratio Performance in Rats Following Massive Transfusion with Cell-Free Resuscitating Solutions,

Descriptive Note:

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH SAN FRANCISCO CALIF

Report Date:

1978-01-01

Pagination or Media Count:

23.0

Abstract:

Rats were trained to perform a fixed ratio FR bar press task in order to obtain food reinforcement. FR operant behavior was then examined daily following 65 percent exchange transfusion with bovine serum albumin BSA, stroma-free hemoglobin SFH or a mixture of those materials. A fourth group of rats controls was subjected to identical surgical and anesthetic procedures, but was not transfused. Average FR response rates of all transfused groups were significantly depressed in comparison to surgical controls 24 hr after exchange transfusion. The degree of this initial response depression was inversely related to baseline FR response rates. Histograms of interresponse times IRTs were also derived. Following exchange transfusion, there were increases in the relative proportions of long IRTs and a slowing of IRTs representing fast response sequences. Changes in FR response rates and in IRT distributions also depended upon the type of transfusion solution employed. Rats transfused with MIX were least affected although the differences between this group and the BSA group were not significant. Rats transfused with SFH showed the greatest initial response decrement. The recovery of the SFH group was also significantly longer than those of the control and MIX groups. There were no significant between-group differences in FR performance by the second week of recovery. Author

Subject Categories:

  • Biochemistry
  • Stress Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE