Recovery of Monkeys from Cardiogenic Shock after Myocardial Infarction with Ventricular Fibrillation - Effects of PGBx.
NAVAL AIR DEVELOPMENT CENTER WARMINSTER PA AIRCRAFT AND CREW SYSTEMS TECHNOLOGY DIRECTORATE
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A polymeric, stable free radical derivative of 15-keto-prostaglandin B, named PGBx, which conserves oxidative phosphorylation in mitochondria under degenerative conditions in-vitro, was studied for its effect on the survival of primates subjected to cardiogenic shock following induced ventricular fibrillation VF in male rhesus monkeys 5-9kg anesthetized with pentobarbital. VF was induced in all animals 20 minutes and maintained sequentially for 4, 6, 8, 12 and 24 minutes in successive periods with 20-30 minute recovery intervals when the animal survived the fibrillation episode. Recovery was established by the maintenance of effective blood pressure without exogenous support. In the control series the cumulative survival for the sequential fibrillation periods of 4, 6, 8, and 12 minutes was 60, 44, 31 and 25 percent. For the PGBx treated series survival for equivalent VF periods was 100, 94, 94 and 88 percent. The difference was highly significant statistically.
- Medicine and Medical Research