Pulmonary Gas Transport and the Regulation of Ventilation at Rest and Exercise.
Final rept. 1 Jan-30 Jun 72,
COLORADO UNIV DENVER MEDICAL CENTER
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During this report period work concentrated on the following topics 1 A Theoretical and experimental study of the 02 uptake by blood in the human lung and in the artificial membrane oxygenator. The rate of oxygen uptake by blood under various conditions is of physiological interest as well as of clinical importance. This work includes a study of blood oxygenation in a tubular membrane oxygenator under controlled conditions with the purpose of determining the parameters governing the oxygen transport under these conditions. 2 An improved method for measuring the CO diffusing capacity was developed. Earlier methods had the shortcomings of requiring end-tidal gas samples or an arterial blood sample. A new steady state method which does not require end-tidal sampling or invasion of the subject is described and 3 Pentobarbital is a commonly used drug as a premedication for anesthesia and surgery. Hypoxia is always a danger during anesthesia and this report describes an investigation of the depression of the ventilatory drive mechanisms. It is anticipated that this work will better allow clinicians to predict the patients in whom administration of this drug would result in depression of hypoxic ventilatory drive.
- Anatomy and Physiology