Cellular Transfer of Cutaneous Sensitivity to Hemolytic Streptococci.
Final rept. 1963-1975,
NEW YORK UNIV MEDICAL CENTER N Y
Pagination or Media Count:
Transfer Factor TF has emerged as one of the more potent immunologic reagents proven effective in the initiation, augmentation or reconstitution of delayed hypersensitivity DTH and cell-mediated immunity CMI in humans. TF is a small 10,000 M.W. non-antigenic, non-immunoglobulin moiety that is separated from the macromolecules of human blood leukocytes by dialysis, further purified by Sephadex fractionation and concentrated by lyophilization. Dialysable TF TFD and the partially purified Sephadex fractions possess the immunological activities of the viable leukocytes from which it is prepared, namely TF confers on the normal recipient for prolonged periods the DTH and CMI possessed by the immune donor. The established effectiveness of TFD is selectively augmenting cellular immunity has fostered its widespread application in the immunotherapy of a variety of congenital and acquired diseases characterized by deficient CMI. Operationally TFD administration results in the appearance of a new population of antigen-responsive lymphocytes in the recipients circulation which in the presence of the related antigen express the activities of the natively immune cell. In addition to the antigen-specific responses, TFD administration results in a nonspecific augmentation of CMI responses.
- Medicine and Medical Research