Evaluation of a Nuclease-Resistant Derivative of Poly(I) Poly(C) (Poly(ICLC)) as a Radioprotective Agent 1, 2.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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The synthetic double-stranded ribonucleic acid, polyriboinosinic acid polyribocytidylic acid polyI polyC is an interferon inducer, has antiviral and antitumor properties, and has been shown to be radioprotective in rodents. The observation that the radioprotective action of polyI polyC, as well as certain endotoxins and chemicals, may be associated with their ability to induce interferon, has also stimulated interest in the possible radioprotective action of interferon itself.