Immunologic Interrelationships of Coliform Heat-Labile and Heat-Stable Enterotoxins.
Annual progress rept. no. 3, 1 Jun 77-15 Feb 78,
ROCHESTER UNIV N Y SCHOOL OF MEDICINE AND DENTISTRY
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The goal of these studies is the development of an immunization program to prevent diarrheal disease due to intestinal contamination by toxigenic strains of coliform bacteria. Immunologic cross reactivity between cholera toxin and E. coli heat-labile LT toxin is well recognized. We showed that this immunologic interrelationship extends to the LT toxins of Klebsiella pneumoniae and Enterobacter cloacae and, in some instances, to the low molecular weight heat-stable ST toxins elaborated by these coliform bacteria. Author
- Medicine and Medical Research