Accession Number:

ADA051277

Title:

2-Deoxy-D-Glucose Induced Hypothermia: Thermoregulatory Pathways in the Rat,

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MASS

Personal Author(s):

Report Date:

1976-08-01

Pagination or Media Count:

34.0

Abstract:

2-DEOXY-D-glucose 2-DG elicits significant and prolonged hypothermia in a variety of animals when administered either peripherally or centrally. From our current studies it would appear that in high concentrations 250 mgkg, i.p. or more 2-DG can act directly on peripheral tissues in the rat by competitively interfering with glucose metabolism and consequently with normal heat producing mechanisms. When a low concentration of 2-DG 20 micrograms is injected centrally, the ensuing glucopenia results in vagal stimulation and subsequent diminuition of peripheral heat production. This is based on studies with atropine which demonstrated a total inhibition of the usual depression in body temperature following the administration of 2-DG into the ventral preammillary nucleus PMV, a site normally extremely sensitive to this analogue of glucose. Additionally, from studies with PMV-lesioned rats, it was concluded that an intact nucleus is necessary for normal thermoregulation during exposure to either hot or cold environments. Author

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE