Increased Survival with Methylprednisolone Post-Treatment in Lethal Endotoxin Shock.
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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The use of corticosteroids has long been intensively studied for the treatment of septic shock however, there still remains much controversy over their use. This study was designed to determine the therapeutic value of post-treatment with methylprednisolone sodium succinate MP in the awake and anesthetized canine receiving LD100 of E. coli endotoxin by either intravenous slow infusion or bolus injection. The MP was administered initially at 15 minutes post-endotoxin at a 30 mgkg body weight dose and then followed at 90 minutes with a maintenance dose of 15 mgkg by slow infusion over a 120-minute period. It was found that post-treatment with MP produced a significant increase 83 in survival in dogs receiving LD100 E. coli endoxtoxin 2.25 mgkm by slow infusion whether awake or sodium pentobarbital anesthetized. Both the 5-hour infusion and bolus injection of the endotoxin 2.25 mgkg produced a 100 mortality with no post-treatment. Post-treatment with the MP did not alter the 100 mortality in the canine bolus injected endotoxin shock model. Survival was associated with a normoglycemia and stablized hematocrit, while death was accompanied by hypoglycemia and severe hemoncentration. Author
- Medicine and Medical Research