Behavioral Effects of Massive Transfusion with Cell-Free Resuscitating Solutions,
LETTERMAN ARMY INST OF RESEARCH SAN FRANCISCO CALIF
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Fixed ratio FR and DRL differential reinforcement of low response rates operant behavior of rats was examined following 65 percent exchange transfusion with bovine serum albumin BSA, stroma-free hemoglobin SFH, or a mixture MIX of these materials. Transient performance decrements were observed following transfusion with each solution. FR response rates of transfused animals were significantly depressed in comparison to surgical controls 24 hrs after exchange transfusion, but differences between transfused groups were not significant. There were no significant differences in FR response rates between the surgical control, hemoglobin-albumin, and albumin groups after the first daily test session. Response rates of the SFH group remained significantly lower in comparison to all other groups through the fourth day of testing. Transfusion related changes in DRL performance were similar to those observed with the FR task. Behavioral recovery appeared to be complete in all animals by the second week of testing.
- Medicine and Medical Research