Accession Number:

ADA050538

Title:

Morphine Depression of Ventilatory Response to Hypoxia, and Reversal by Naloxone,

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MASS

Report Date:

1977-01-01

Pagination or Media Count:

24.0

Abstract:

Ventilatory response to isocapnic hypoxia was measured in awake beagle dogs prior to and following administration of intravenous morphine sulfate, 0.6 mgkg. Hypoxic ventilation was depressed within 30 minutes, was maximally depressed at one to two hours, and remained depressed for at least six to seven hours following the administration of morphine. Naloxone, 0.4 mg IV, completely reversed the morphine depression of the ventilatory response to hypoxia, but only transiently 30 to 45 minutes after naloxone reversal, the ventilatory respone to hypoxia was again significantly depressed. Naloxone alone demonstrated mild agonist properties on the ventilatory response to hypoxia, but the effect varied among the dogs. Author

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE