The Ganglionic Blocking Properties of the Cholinesterase Reactivator HS-6.
DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
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Following I.V. administration of 30 mgkg of the cholinesterase reactivator HS-6, blood pressure fell up to 50 mmHg and maximal blood levels of HS-6 reached 242 microgramsml. HS-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation. Doses of HS-6 below those tested therapeutically against soman in different animal species 3.59-10.77mgkg progressively blocked the ganglion stimulating effects of nicotine and dimethylphenylpiperazinium but not those following adrenaline, a pattern similar to that produced by hexamethonium but only 184 as potent. HS-6, like hexamethonium and mecamylamine, progressively blocked the contraction of the nictitating membrane of the cat resulting from pre-ganglionic stimulation. The results indicate that HS-6 possesses ganglion blocking properties at doses likely to have any any value therapeutically in soman poisoning. The ganglion blocking properties of the drug may be a factor in the beneficial effects of HS-6. Author
- Medicine and Medical Research