Accession Number:

ADA050007

Title:

The Effect of Prostaglandin E1 on the Course of Decompression Sickness in Dogs.

Descriptive Note:

Medical research progress rept.,

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1977-10-01

Pagination or Media Count:

19.0

Abstract:

A double-dive technique was used to produce neurological symptoms of decompression sickness in four air-breathing dogs. The neurological deficit was quantitatively scored and then an intravenous infusion of Prostaglandin E1 PGE1 was given at a dose rate of 10 microgramskgminute. The results were compared to those previously obtained when using a similar technique to investigate other therapeutic agents in the treatment of decompression sickness. There was no evidence of any improvement in the clinical condition of the dogs treated with PGE1 and rapid deterioration and death occurred in 3 out of 4 animals. This may indicate that PGE1 has an actively deleterious effect on dogs with neurologic manifestations due to severe decompression sickness. Author

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE