Regulation of Gingival cAMP Levels: Effects of Inflammation and Surgery.
Rept. for 1 Dec 75-17 Nov 77,
ARMY INST OF DENTAL RESEARCH WASHINGTON D C
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The basal levels of the nucleotide cAMP in gingiva and the relationship of these levels to gingival tissue health was determined in Rhesus monkeys. It was shown that tissue cAMP levels were negatively correlated to gingival inflammation. Inflamed gingiva showed lower tissue cAMP levels than healthy gingiva. In addition, the effect of surgery on tissue cAMP levels was investigated. It was shown that the levels of cAMP in the tissues progressively decreased as flaps were reflected for 30, 60, or 120 minutes. It is proposed that the reduction in cAMP content of the gingival flaps may affect collagen synthesis and retard clinical healing of tissues after lengthy surgical procedures. Author
- Medicine and Medical Research