The Role of Inorganic Phosphate in Oxygen Transport.
Annual progress rept. 1974-1975,
CALIFORNIA UNIV SAN FRANCISCO
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The studies are based on assessment of inorganic phosphate and its modulation of oxygen transport by virtue of its effect on the production of glycolytic intermediates, primarily 2-3 diphosphoglycerate and adenosine triphosphate. The interaction of these systems with the red cell results in modulation of the oxyhemoglobin dissociation curve and, by inference, oxygen delivery to tissue. The studies herein reported establish the very significant feature of the continued dissection of the Fick equation in that we have demonstrated that tissue oxygen tension is the best predictor of systemic oxygen transport. Systemic oxygen transport STO2 is the measure by which blood flow, hemoglobin, P50 of the oxyhemoglobin curve, are combined in total assessment of oxygen delivery. Establishment of the correlation between systemic oxygen transport and tissue oxygen tension has significance for the totality of oxygen transport as well as suggesting that tissue oxygen tension may have important use as a minimally invasive monitor in many situations of critical illness. It also has the advantage of being readily available and capable of being used in unusual systems of transport of victims.