Accession Number:

ADA048215

Title:

Immunological Studies on Herion Addiction.

Descriptive Note:

Final rept. Jul-Sep 75,

Corporate Author:

PUBLIC HEALTH RESEARCH INST OF THE CITY OF NEW YORK INC

Personal Author(s):

• Liu,Chi-Tan
• Adler,Frank L.

Report Date:

1975-10-01

Pagination or Media Count:

10.0

Abstract:

Hemagglutination-inhibition HI procedures for the detection of morphine, methadone and barbiturates have been devised, developed and validated to the point of their adoption by diagnostic laboratories, and the necessary reagents have become available through commercial sources. The HI test for the detection of the major cocaine metabolites suffers from interference by unidentified substances found in some human urine specimens. After appropriate adjustment for this interference the test detects cocaine metabolites for about 4 days after last use of the drug. HI tests for detection of amphetamine and LSD have yet to be completely developed. The application of serological methods for the study of pharmacokinetics has been critically examined and the results have been submitted for publication. Finally, the generation of specific antibodies in response to morphine administration has been verified, but the biological significance of this phenomenon remains in question. Author

Descriptors:

• *DETECTION
• *SENSITIVITY
• *IMMUNIZATION
• *DRUG ADDICTION
• CHEMICAL REACTIONS
• ANTIBODIES
• IMMUNOLOGY
• IMMUNOASSAY
• SEROLOGY
• COCAINE
• METABOLITES
• SERODIAGNOSIS
• DRUG ABUSE
• HEROIN

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE