Accession Number:

ADA046969

Title:

Hydrolysis of Enkephalin by Cultured Human Endothelial Cells and by Purified Peptidyl Dipeptidase

Descriptive Note:

Technical rept.

Corporate Author:

TEXAS UNIV HEALTH SCIENCE CENTER AT DALLAS

Report Date:

1977-11-01

Pagination or Media Count:

12.0

Abstract:

The experiments indicate that rapid inactivation of enkephalins may be due to at least two different enzymes present in tissues. A peptidyl dipeptidase which is a component of plasma membrane of various cells may degrade enkephalins by liberating a C-terminal dipeptide and an aminopeptidase in endothelial cells may cleave peptides, that they are taken up as blood flows past the endothelial surface, at the N-terminal end.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE