Hydrolysis of Enkephalin by Cultured Human Endothelial Cells and by Purified Peptidyl Dipeptidase
TEXAS UNIV HEALTH SCIENCE CENTER AT DALLAS
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The experiments indicate that rapid inactivation of enkephalins may be due to at least two different enzymes present in tissues. A peptidyl dipeptidase which is a component of plasma membrane of various cells may degrade enkephalins by liberating a C-terminal dipeptide and an aminopeptidase in endothelial cells may cleave peptides, that they are taken up as blood flows past the endothelial surface, at the N-terminal end.