Chemotherapy of Rodent Malaria Evaluation of Drug Action Against Normal and Resistant Strains, Including Exo-Erythrocytic Stages
Final technical rept. 31 Oct 1975-31 Dec 1976
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (UNITED KINGDOM) DEPT OF PARASITOLOGY
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Data are provided on the blood schizontocidal action of 8 WRAIR compounds and the tissue schizontocidal activity of a total of 110 WRAIR 8- aminoquinolines plus 29 other compounds. Emphasis is laid on the comparison of new series of 5-substituted 8-aminoquinolines and comparison has been made between data obtained in our rodent models and reports on work in simian models from other investigators. A good parallel was found with tissue schizontocidal activity. The administration of mixtures of mefloquine with pyrimethamine, sulphaphenazole or primaquine has been shown to enhance the development of resistance by P. berghei to the individual components. Studies have continued on the modes of action of mefloquine, chloroquine and quinine. Mefloquine has been shown to have relatively little effect on the uptake of adenosine. The synergistic action of chloroquine and erythromycin against chloroquine-resistant parasites has been further investigated. The mechanism of this synergism is still obscure. Other work has involved the study of electron transport and cathepsins of rodent malaria parasites.