Synthetic Analogs of Phospholipid Metabolites as Antimalarials.
Annual progress rept. 1 Jul 76-30 Jun 77,
LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY
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Initial years progress is described toward the synthesis of analogs of phospholipids and of their biosynthetic intermediates as possible antimalarials of a new type. Emphasis was placed on phosphonic and phosphinic acid analogs of lecithin, phosphatidic acid, cytidine diphosphate diglyceride, and cytidine diphosphate choline. Nine compounds were submitted of which one was a major target and three were secondary target compounds. None of the substances so far tested showed appreciable antimalarial activity. Author