Accession Number:

ADA046528

Title:

Synthetic Analogs of Phospholipid Metabolites as Antimalarials.

Descriptive Note:

Annual progress rept. 1 Jul 76-30 Jun 77,

Corporate Author:

LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY

Personal Author(s):

Report Date:

1977-09-28

Pagination or Media Count:

38.0

Abstract:

Initial years progress is described toward the synthesis of analogs of phospholipids and of their biosynthetic intermediates as possible antimalarials of a new type. Emphasis was placed on phosphonic and phosphinic acid analogs of lecithin, phosphatidic acid, cytidine diphosphate diglyceride, and cytidine diphosphate choline. Nine compounds were submitted of which one was a major target and three were secondary target compounds. None of the substances so far tested showed appreciable antimalarial activity. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE