Evaluation of Pulmonary and Cardiovascular Effects of New Antimalarial and other Antiparasitic Compounds.
Annual progress rept. no. 1, Jul 75-30 Jun 76,
TENNESSEE UNIV CENTER FOR THE HEALTH SCIENCES MEMPHIS
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Mefloquine methanesulfonate WR-142,490.CH3SO3H, when infused at a dose -rate of 1 mgkgmin for 20 minutes in the anesthetized dog, caused either little or no effect on the pulmonary and cardiovascular parameters measured during this drug infusion or in the following 3 hour observation period. However, dose-rates of 2 and 3 mgkgmin of mefloquine MS for 20 minutes did produce pulmonary and cardiovascular changes. The respiratory parameters which were observed to change were 1 tidal volume, which fell during the drug infusion but then returned to control values during the remaining portion of the observation period 2 respiratory rate, which rose during the drug infusion but returned to control levels 3 dynamic airways resistance, which fell during drug administration but then rose above control levels and 4 small gradual changes in blood pO2 and pCO2. High dose-rate infusion of mefloquine MS of 8 or 10 mgkgmin, by the i.v. route, produced a dramatic drop in blood pressure, heart rate and tidal volume and equally marked elevations in respiratory rate and pulmonary artery pressure. Pulmonary wedge pressure was also slightly elevated.