A Neuropsychological Basis for Drug Substitution.
Annual progress rept. no. 8, Oct 73-Oct 74,
UTAH UNIV SALT LAKE CITY DEPT OF PSYCHOLOGY
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The effects of librium, meprobamate, chloral hydrate, pentobarbital, paraldehyde and ethanol upon brain thresholds is detailed. In addition, the sequence of changes of the reticular formation and the caudate nucleus during the acquisition of physical dependence to pentobarbital, and also during withdrawal from pentobarbital is described. It was hypothesized that the development of drug dependence is characterized by a double dissociation, the peripheral nervous system from the central nervous system and the motor system from the arousal system. Author