Accession Number:

ADA046051

Title:

Electron-Microscopic Evaluation of the Hepatotoxicity of Selected Hydrocarbons

Descriptive Note:

Final rept. Nov 1975-Jan 1977

Corporate Author:

RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER CHICAGO IL

Report Date:

1977-09-01

Pagination or Media Count:

19.0

Abstract:

Morphometric analyses of livers of mice exposed to chlorobromodifluoromethane H-1211, chlorobromomethane H-1011, or phenobarbital were performed using electron-microscopic techniques. The data indicate that exposure to phenobarbital induced a significant increase in the surface area of smooth endoplasmic reticulum SER. In contrast, neither H-1211 or H-1011 induced statistically significant increases in the surface area of SER. The ultrastructural appearance of the livers of animals exposed to both of the fluorocarbons was essentially normal although there was increased glycogen deposition in the H-1011 treated livers.

Subject Categories:

  • Biochemistry
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE