Accession Number:

ADA045830

Title:

Environmental Stress and Biochemical Adaptation.

Descriptive Note:

Final rept. 1971-1977.

Corporate Author:

INDIAN INST OF SCIENCE BANGALORE DEPT OF BIOCHEMISTRY

Personal Author(s):

Report Date:

1977-05-01

Pagination or Media Count:

27.0

Abstract:

The regulation of mitochondrial succinate dehydrogenase under conditions of environmental stress and treatment with diverse class of activators, including ubiquinol, with the common features of 5.4 0.8 a have been studied which led to the appreciation of the importance of this enzyme and redox status of ubiquinone in regulation of energy metabolism. The combined action of the two stress hormones, cortisol and noradrenaline, stabilizes the new steady-state levels of the enzymes in the catabolism of aromatic amino acids--tryptophan pyrrolase, tyrosine aminotransferase and phenylalanine hydroxylase. The observations that enzyme induction and body temperature decreased on treatment with some drugs under cold-exposure point to the need of qualification of environmental conditions for specifying drug action. Based on these findings models for chemical thermogenesis, acclimation process and functional role of protein structure has been proposed which are expected to stimulate further experiments. Author

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE