Host Defense Against Opportunist Microorganisms Following Trauma.
Annual summary rept. no. 2, 1 Jul 76-30 Jun 77,
CINCINNATI UNIV OHIO COLL OF MEDICINE
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Studies were performed to determine the effects of septicemia on humoral components of host defense in burned patients. Conversion of C3 by inulin, total hemolytic complement CH50, and immunochemical levels of C1, C4, C2, C3, C5, factor B, C3b inactivator KAF, and properdin were measured in fifteen patients with severe thermal injury during nine weeks postburn. To determine if the changes in complement components and immunoglobulins which were observed in the septic and non-septic burned patients were unique to patients with burn injury, levels of components of the alternative and classical complement pathways and of immunoglobulins were measured in the sera of ten patients with blunt or penetrating abdominal trauma and in ten septic patients without trauma. Experiments were also performed to investigate the humoral mechanisms which are operative against gram-negative aerobic and anaerobic opportunist microorganisms which cause serious infection in trauma patients. intact cells of E. coli 075, wild-type S. minnesota, and clinical isolates of P. aeruginosa and P. mirabilis were found to be capable of efficiently activating the alternative pathway.
- Medicine and Medical Research
- Weapons Effects (Biological)