Prevention of Hemoglobinuric Nephrosis.
Final scientific rept. 1 Feb 73-31 May 75,
SCRIPPS CLINIC AND RESEARCH FOUNDATION LA JOLLA CA DIV OF HEMATOLOGY-ONCOLOGY
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Intravenous injection into rabbits, baboons and humans of large volumes of hemoglobin in frozen-thawed blood caused hemoglobinuria without any evidence of renal disturbance, nor was there evidence of clinically significant disseminated intravascular coagulopathy DIC. The rate of urinary hemoglobin excretion was determined. In the baboon, the simultaneous injection of dextran solution did not modify the rate of hemoglobin excretion. In one patient with nocturnal hemoglobinuria, infusion of dextran solution was associated with decreased hemoglobin excretion. Author
- Medicine and Medical Research