Accession Number:

ADA043905

Title:

Prevention of Hemoglobinuric Nephrosis.

Descriptive Note:

Final scientific rept. 1 Feb 73-31 May 75,

Corporate Author:

SCRIPPS CLINIC AND RESEARCH FOUNDATION LA JOLLA CA DIV OF HEMATOLOGY-ONCOLOGY

Personal Author(s):

Report Date:

1977-04-01

Pagination or Media Count:

6.0

Abstract:

Intravenous injection into rabbits, baboons and humans of large volumes of hemoglobin in frozen-thawed blood caused hemoglobinuria without any evidence of renal disturbance, nor was there evidence of clinically significant disseminated intravascular coagulopathy DIC. The rate of urinary hemoglobin excretion was determined. In the baboon, the simultaneous injection of dextran solution did not modify the rate of hemoglobin excretion. In one patient with nocturnal hemoglobinuria, infusion of dextran solution was associated with decreased hemoglobin excretion. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE