Studies on the Antigenic Composition of 'Coxiella burnetii'.
Annual progress rept. 1 Jul 76-30 Jun 77,
WASHINGTON STATE UNIV PULLMAN
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The in vitro resistance of mice to infection with C. burnetii was evaluated using various immunosuppressive agents. Spleen impressions of control mice indicated that maximal infection occurred during the first week, after which time C. burnetii was rapidly cleared from the spleen. Treatment of mice prior to C. burnetii infection with ALS, AMS, or silica i.p. failed to cause lethal infection, however, spleen impressions from these treated animals demonstrated that clearance of rickettsiae from the spleen occurred at a much slower rate when compared to control infected animals over the same time period. Cyclophosphamide treatment prior to infection was found to cause 100 mortality within 10 days post infection. When silica was administered intravenously it was found that a lethal event could be induced.