Inhalation Toxicology: I. Design of a Small-Animal Test System. II. Determination of the Relative Toxic Hazards of 75 Aircraft Cabin Materials.
Rept. for Oct 74-Sep 76,
FEDERAL AVIATION ADMINISTRATION WASHINGTON D C OFFICE OF AVIATION MEDICINE
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In an effort to further the cause of increased safety for those who ride in commercial aircraft, this paper presents a detailed description of the genesis of a small-scale, laboratory test system that utilizes small animals to evaluate the relative toxic hazard of combustion products generated by the thermal decomposition of nonmetallic materials. It includes a discussion of the concepts that led to the design detailed instructions for fabricating the system operating parameters and instructions for conducting a test an evaluation of the systems performance as determined by the testing of 75 aircraft cabin materials the utilization of animal response time as a basis for expressing relative toxicity and a discussion of the derivation of an inhalation dose concept that promises to be more useful than lethal concentrations. Author