Enterotoxic Shock in Rhesus Monkeys: The Role of Selected Blood-Borne Factors.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Staphylococcal enterotoxin B, a protein exotoxin from Staphylococcus aureus, produced progressive hypotension and shock when injected 1 mgkg, intravenous into rhesus monkeys. Plasma levels of factors which have been implicated in the pathogenesis of other types of shock were measured. Endotoxin-like activity ELA was measured by the Limulus lysate technique, fibrin degradation products FDP were quantified by electroimmunoassay, and activation of the complement system was assayed by measuring total hemolytic complement. Activation of the intrinsic coagulation cascade was assessed by measuring activated partial thromboplastin time APTT. Activation of the kinin system was evaluated by measuring prekallikrein activity and kininogen. Myocardial depressant factor MDF was measured by paper chromatography. ELA did not appear in plasma, and the complement system was not activated. The appearance of FDP and significant trend for prolongation of APTT indicated activation of fibrinolysis and the intrinsic coagulation cascade, and suggested that disseminated intravascular coagulation DIC was occurring.
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