Venezuelan Equine Encephalomyelitis: Protective and Toxic Effects of a Nuclease-Resistant Derivative of Poly(I)-Poly(C).
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
Pagination or Media Count:
Polyriboinosinic-polyribocytidylic acid stabilized with poly-1-lysine and carboxymethylcellulose, poly ICLC, favorably alters the pathogenesis of Venezuelan equine encephalomyelitis infection in rhesus monkeys by decreasing the number of monkeys that become detectably viremic and by delaying the onset of viremia in the remaining monkeys. PolyICLC is known to induce high, circulating levels of interferon in primates and the interferon system is assumed to be the mechanism by which polyICLC exerts its antiviral activity. Poly-ICLC treatment was associated with mortality only under certain conditions of infection and handling. The death of some infected-treated monkeys in the absence of death in monkeys that were either infected and untreated or treated and uninfected suggests a synergistic toxicity resulting from the combination of infection, handling and polyICLC treatment.
- Medicine and Medical Research