In Vitro and In Vivo Actions of Zinc Ion Affecting Cellular Substances which Influence Host Metabolic Responses to Inflammation.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD
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Glycogen-stimulated rabbit peritoneal exudate cells polymorphonuclear leukocytes, PMN product prostaglandins PG and substances which induce alterations mediators in experimental animals characteristic of host metabolic responses to infection and other acute inflammatory stresses. The effect of Zn2 on mediator production and PG synthesis was examined. Using exudate cells, 2 mM Zn2 caused complete inhibition of in vitro PG synthesis as assessed by conversion of 1-14C arachidonic acid into PG. This concentration of Zn2 also inhibited production of substances mediating plasma Zn depression, hepatic amino acid uptake, fever, and neutrophil release from bone marrow. Conversely, Zn2 did not inhibit in vivo metabolic responses to these mediators. Zn-pretreatment of rabbits or simultaneous injection of Zn2 and crude PMN-derived pyrogenic activity resulted in prolongation of fever.
- Medicine and Medical Research